- S-Core (French metal band)
- S.O.D. (thrash band Stormtroopers of Death)
- S.P.O.C.K
- S.T.U.N.
- S.U.N. Project
- S3P (S3P are an electronic rock band from Moscow.)
- Sabaton
- Sabbat (England)
- Sabina, Joaquín
- Sac, Dan le vs. Scroobius Pip
- Sacred Reich
- Sacred Steel
- Sacrifice (Canadian thrash metal band)
- Sacrificium
- Sad Lovers and Giants
- Sade (Group w/ singer of same performance name)
- Sadies, The
- Sadist
- Sadus
- Saez
- Safetysuit
- Saft, Jamie, Trio
- Saga (A progressive rock quintet, formed in Canada in 1977)
- Sahg
- Saïan Supa Crew
- Saigon Kick
- Saint Etienne
- Saint James, Rebecca
- Saint Vincent
- Saint Vitus
- Sainte-Marie, Buffy
- Saints, The
- Sala, Pep
- Saliva
- Salmonella Dub
- Saltatio Mortis
- Samael
- Samantha 7
- Samba
- Sambora, Richie
- Samhain
- Samiam
- Samsas Traum
- Samson
- Samson, John K.
- Samuel Jackson Five, The
- San Pascualito Rey
- Sanborn, David
- Sanctity
- Sanctuary (Metal band with Nevermore singer Warrel Dane)
- Sanctus Real
- Sanders, Pharoah
- Sanseverino
- Santana
- Santana, Carlos
- Santogold
- Santolla, Ralph
- Santos, Lulu
- Sanz, Alejandro
- Saosin
- Saratoga (Spanish metal band)
- Saraya
- Sardinas, Eric
- Sariñana, Ximena
- Sarke (the band)
- Sartain, Dan
- Sasha (German pop artist)
- Sasha (UK trance DJ and producer)
- Satanic Slaughter
- Sator
- Satriani, Joe
- Saturdays, The
- Satyricon
- Saule (Belgian singer of Saule et les Pleureurs)
- Sauron (Metal band from USA, Michigan)
- Savage (heavy metal)
- Savage Circus
- Savage Garden
- Savage Messiah
- Savage Republic
- Savatage
- Save Ferris
- Saves the Day
- Saving Abel
- Saviour Machine
- Saw Doctors, The
- Saxon
- Saxon Shore
- Say Anything
- Say Hi
- Say Hi to Your Mom
- Saybia
- Sayyadina (Swedish grindcore band)
- SBB
- Scabs, The (Belgian rock band)
- Scaggs, Boz
- Scale The Summit
- Scandal (80s US rock band fronted by Patty Smyth)
- SCANDAL (Japanese Girl Pop/Rock)
- Scanner (Robin Rimbaud)