- U.D.O.
- U2 (Irish rock band)
- U2 (??????)
- Uaral
- UB40
- Ubiquitous Synergy Seeker
- Udo
- UFO (70's - 80's British Space-Rock/Hard Rock band)
- UFO (Latvian DJ)
- Ufomammut
- Uggla, Magnus
- Ugly Casanova
- Ugly Kid Joe
- Uh Huh Her
- UK (British progressive rock supergroup)
- UK Subs
- Ulmer, James Blood
- Ultra Vomit
- Ultraje a Rigor
- Ultrasound
- Ultravox
- Ulver
- Ulysses (tech house artist Elliot Taub)
- Umbra et Imago
- Umphrey's McGee
- Un Kasa
- Uncle Ho
- Uncle Kracker
- Uncommonmenfrommars
- Under Byen
- Under the Influence of Giants
- Under, Alex
- Underoath
- Undertakers (Italian death metal band)
- Undertones, The (northern irish punk rock band)
- Underwood, Carrie
- Underworld
- Undish
- Unearth
- Unearthly Trance
- Unexpect
- Unfinished Sympathy, The
- Unheilig
- Unified Theory (ex-Blind Melon and ex-Pearl Jam alternative rock super group)
- Union (Hard Rock band featuring John Corabi and Bruce Kulick)
- Union Underground, The
- Union, The (released record on Grass Records)
- Unisex, The
- UNKLE
- Unleashed (Swedish death metal band)
- Unloco
- Untoten
- Unwritten Law
- Uochi Toki (Italian hip-hop band)
- Upshot
- Upside Down
- Upwelling, The
- Urban & 4
- Urban Dance Squad
- Urban, Keith
- Urbane, The
- Ure, Midge
- Urge Overkill
- Uriah Heep
- Urlaub, Farin
- Urlaub, Farin, Racing Team
- Urszula
- Urthboy
- Used, The
- Usher
- Usher, David
- Usurper
- Utada
- Utah Saints
- Utopia (US progressive rock band led by Todd Rundgren)
- Uzômi